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Our preliminary results demonstrate that, when using a linear array photoacoustic system, TYR-expressing cells can be visualized through 4 cm of chicken tissue (data not shown), suggesting that it may be possible to image gene expression at greater imaging depths using TYR and photoacoustic imaging compared to conventional optical-based reporter genes.
In situations in which translucency and immobility enable live imaging – in particular in the embryo and pupae – it will be possible to image events such as the translocation of fluorescently tagged transcription factors from cytoplasm to nucleus.
Therefore, it may be possible to image the progress of slip deficit at larger scales if the changes in slip activity on small patches are detectable.
It will not be possible to image the tumor if that it has very limited or no receptor expression even if the receptor ligand has high receptor binding affinity.
An increased contrast was expected due to the lack of out-of-focus fluorescence, such that it should be possible to image and track smaller (and faster) molecules at the single molecule level than ever before [24].
Alternatively, it should be possible to image HP 129Xe in both phases within a single breath using an interleaved radial acquisition that alternates between the exciting the gas and the dissolved phases.
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For instance, combining spatially offset Raman spectroscopy (SORS) with three-dimensional tomographic imaging, it was possible to image a canine hind limb section of a thickness of up to 45 mm using transmission Raman spectroscopy [ 40, 41].
Using [68Ga]GaCl3, it was possible to image vasculature in mice with CLI.
Sometimes it is possible to image formation of a sequesters, especially when surrounded by pus (Fig. 9).
Additionally, it is possible to image a range of materials for which non-destructive testing is important, such as graphite rods used in the nuclear industry.
Although CEUS is mainly used to assess an isolated injury on one flank [30], it is possible to image more than one abdominal organ.
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