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This may be possible by modulating receptors using allosteric ligands, which interact with the receptor at a binding site topographically distinct from the endogenous ligand.
Up-regulating HK2 expression in the heart provides another potential means of increasing mitochondrial HK2 binding, and this may be possible by modulating levels of the microRNAs miR-155 and miR-143.
Even if blockade of Notch signaling alone is insufficient to activate neurogenin-3 expression and initiate islet cell neogenesis in mature pancreatic cells, activation might be possible by modulating other signaling pathways, including GDF11-TGFβ (Yamaoka et al., 1998; Hald et al., 2003; Kodama et al., 2005; Baeyens et al., 2006), either alone or in conjunction with Notch blockade.
Coordination influences may vary in strength depending on the actual context as studied for curve walking by Dürr (2005) and Dürr and Ebeling (2005), which, in Walknet, would be possible by modulating rules' strength using additional motivation units (as depicted in Fig. 4).
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shermanii JS) and prebiotic galactooligosaccharides demonstrated that the prevention of atopic eczema in high-risk Finnish infants is possible by modulating the infants' gut microbiota with probiotics and prebiotics.
Thus, changes in patterns of callose synthesis at the pollen mother cell must be balanced with the selective pressures that lead to a nearly universal presence of callose plugs; such changes would be possible by differentially modulating sporophytic and gametophytic CALS5 expression profiles.
Thus, it is possible that by modulating HSP activity curcumin might inhibit or slow down amyloid formation and eventually reduces neuronal death in different neurodegenerative diseases.
Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in human primary MSCs, and whether it was possible by such an approach to modulate the appearance of chondrogenic hypertrophy in pellet cultures in vitro.
The grading of Ga is also possible by modulating the current density during electroplating [62].
In particular, it is possible to modulate film stiffness by physical or chemical cross-linking.
These results further support the hypothesis that it is possible to modulate the product formation by limiting key nutrients during C. ragsdalei syngas fermentation.
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