Sentence examples for be positive modulators of from inspiring English sources

13 Polyamines are known to be positive modulators of NR2B containing N-methyl d-aspartate (NMDA) receptors which are involved in central sensitisation following peripheral nerve injury.

It is known that FFA are positive modulators of insulin secretion in short-time perspective but become toxic to β-cells when chronically present in elevated levels (lipotoxicity) [1], [2], [3], [8], [9], [10].

Also, IGFs are important positive modulators of body and muscle growth in mammals and chickens.

Furthermore, the divalent cation Mg2+ was found to be a positive modulator of the l-ornithine response.

DMPK, a serine/threonine protein kinase has been shown to be a positive modulator of insulin action [ 31].

Calcimimetic agents like NPS R-568 are positive allosteric modulators of the CaSR, which potentiate the effects of the CaSR by interacting with the 7-transmembrane region of the receptor and inducing conformational changes.

Therefore, εPKC appears to be a positive modulator of compensatory cardiac hypertrophy in this mouse model.

DRAM1 is a positive modulator of autophagy and is required for the full execution of p53-induced death.

In higher vertebrates both IRF1 and IRF7 have been implicated as positive modulators of the type I IFN response to viruses, with IRF7 being essential for interferon-related gene expression [ 53].

The neuronal c-Jun N-terminal kinase (jnk-1) is a positive modulator of DAF-16 and is involved in regulating longevity.

Therefore, we proposed that, in the presence of TGF- β1, miR-136 was a positive modulator of keratinocytes proliferation and PPP2R2A was a functional target of miR-136 via binding to its 3′-UTR region.