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– Simply put, the role of this interaction is to facilitate the Ras-dependent recruitment of c-Raf to the membrane where it can optimally be positioned for activation by a collection of additional proteins.
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Based on this model and the biochemical data presented above, we propose that L363E is positioned for water activation and is stabilized by H146 (Figure 4B).
Capital goods businesses are positioned for growth.
And they're positioned for the future".
Corey Perry is positioned for big numbers.
The role that MB would have played in nucleophile activation would no longer be required, as M1/A is now positioned for activation of the second nucleophilic attack.
In this structure, the N3 of cytosine 75 is positioned to act as a general acid for activation of the leaving group.
The bank is beautifully positioned for expansion.
Thus, similar Fis-αCTD interactions are used for activation of transcription when the activator is bound at very different positions on the DNA.
In this way, TALE-TF binding sites will be in optimal position for transcriptional activation (within 200 bp upstream of transcription start sites).
In addition, within the BH3 domain, the h0 position recently found to be important for Bax activation, was important also for Bak activation.
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