The observation that the C-terminal domain is poorly structured in the active oxidized form suggests that the loss of zinc and unfolding of the domain precedes the oxidation of the thiolate groups of the cysteine residues, since the formation of disulfides between distant parts of the domain sequence would presumably promote the formation of stable three-dimensional structure in the oxidized form.
Consequently, the forest dynamics in this forest type have been poorly investigated, as most fragments are poorly structured in terms of tree size and diversity.
While these domains are poorly structured in the constitutive form of prions, they are subject to conformational rearrangements in the form of the protein associated to the prion traits [7] [9].
Studies conducted in this environment tend to be poorly structured or retrospective in nature, frequently providing only partial insight into the condition being investigated.
This model may be poorly structured and unsupported in the context of patients with chronic illness who can require multiple presentations across private medical specialists, community health, general practice, allied health, and hospital inpatient and outpatient clinics.
Comparison of the CD difference spectra of full-length Ure2p and Ure2pC-terminal domain [23] and that of the GST-prion domain fusion and GST reveal however that Ure2p prion domain is poorly structured whether in its natural context or fused to the C-terminal end of GST i.e. establishing interaction with the rest of the protein or not, respectively.
Some critics found the novel too preachy; some, including Leonard Woolf, thought it was poorly structured; some complained of sloppiness in style.
But we agree that the particular sentence in question was poorly structured and had been rewritten for clarity.
But the commutation was poorly structured and announced, leading to a firestorm of controversy.
Overall, the system is poorly structured to address such fundamental issues.
