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We hypothesized that DQ2-CLIP1/2 might be poor substrates for DM.
These findings suggest that OH-PCBs are likely to be poor substrates for sulfonation, but this has not been studied in human liver.
Verapamil (but not sulindac) had an effect on paclitaxel resistance but only in the paclitaxel-selected variants (taxanes are known to be poor substrates for MRP-1).
The AS5-containing polycistronic transcripts appear to be poor substrates for chloroplast RNA processing enzymes, although the smaller species exhibited a 3- to 10-fold greater accumulation in the AS5ox lines than in the WT.
However, strong H-NS stimulation of pausing may allow Rho termination at backtrack sites by increasing the kinetic window for Rho action at the sites as backtracked ECs are known to be poor substrates for Rho (Dutta et al., 2008).
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Overglycosylated hydroxylysines are poor substrates for ε-amino group deamination which initiates cross-link formation.
In aggregate, these results show that C3 cladinose macrolides are good substrates for MphB and other Mphs including MphA32,44 and MphH27 (Supplementary Table 2), but are poor substrates for MphI and MphK.
Whereas the derivatives were poor substrates for plasma enzymes; they were hydrolyzed rapidly to parent bupivacaine in the presence of pancreatic enzymes (simulated intestinal fluid) at 37 °C.
Perhaps more significantly they indicate that the intracellular PrPC molecules were poor substrates for conversion to PrPSc.
It may be that the unfolded proteins are ubiquitinated on the plasma membrane, but escape degradation simply because they cannot be extracted from this membrane and are poor substrates for endocytosis.
Our data do not establish where RAG1/2 proteins bind; therefore they don't discriminate between two possible hypotheses to explain the scarce nicking at Vβ and Jβ RSSs: these RSSs are poor substrates for either RAG binding or for the RAG nicking reaction per se.
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CEO of Professional Science Editing for Scientists @ prosciediting.com