The commonly used EOC cell lines are poor models of HG-SOC, whereas patient-derived xenografts (PDX) retain pathological and immunohistochemical features of primary tumour, providing a valuable preclinical resource for therapeutic exploration.
As such, common nutrient-rich growth media that do not require QS for growth are poor models of in vivo infection growth.
That mouse models are poor models of complex human diseases has been confirmed recently in a very comprehensive evaluation of the genomic response to inflammatory conditions: the genomic response in humans was very similar for inflammatory responses of different etiologies but the various mouse models correlated poorly with the human conditions and poorly with each other [ 270].
Thus our results may provide some insight regarding a handful of recent experimental findings addressing whether mice are poor models of inflammatory diseases [ 35] and if certain immune response genes can only be studied in primates or humans [ 14], for example.
They can hence be poor models for testing and development of novel drugs.
These alternative arrangements produced larger error when used to model all clusters (Table 6), suggesting that they are poorer models of the underlying transcription mechanism.
To address this, mouse and rat models are commonly used; unfortunately, many are poor models for the majority of human diseases [ 6].
These results clearly demonstrate the role of the targeted genes in the filtration barrier, but prove that the transgenic mouse lines generated are poor models for studying the mechanism of sodium retention, mainly because there is no evidence that these mice develop edema and/or ascites.
Second, this penalization allows to avoid regions of the parameter space corresponding to very stiff systems, which are poor numerical models of reality, and which simulation are computationally demanding or simply make the solver fail.
Rabbit is the most commonly used animal species in intravitreal pharmacokinetics, but it has been criticized as being a poor model of human eye.
