However, based on the fact that data were pooled from two large phase III studies, the subgroups were all sizeable (each comprising >900 patients), allowing a clear evaluation of the effects of tiotropium + olodaterol in comparison to the monotherapy components.
Data was pooled from 5 large United Kingdom trials of ASA to prevent vascular disease and examined for the effect of ASA on cancer metastases presenting during the trials or after they ended.
The ligation was scaled up under optimized conditions, and the transformed cells from six electroporations were pooled together for large-scale production.
Mike Vieira, owner of a small dairy west of Spokane that produces about 250 gallons of milk a day, said the scare might be good for his business because customers know where his milk comes from, as opposed to milk from larger dairies that is pooled at a processing plant.
However, milk in large containers was likely pooled from different sources, which is considered a risk factor for increased microbial load (Younan and Abdulrahman 2004).
Cytogenetic risk classifications are often ascertained from pooled data from large randomized studies, and are based on the treatment outcome from patients below the age of 60.
As already mentioned above, strains with improved flavor production cannot be easily selected from large pools of variants, and therefore, many improvement strategies targeting this phenotype, such as genome shuffling or directed evolution, require testing of individual clones.
Since the late nineteen-sixties, when patients with hemophilia began to use clot-promoting proteins that were derived from large pools of donor blood, they had been vulnerable to infection, especially hepatitis.
Each CO2 capture process is optimized, and the best materials are screened from large pool of candidate materials.
The non-biological proteins that emerge from these selections are discovered in much the same way that aptamers are selected from large pools of DNA and RNA [3].
