Locus AT3G20820, also an LRR gene, is polymorphic for a single stop codon in both Sweden and Germany, and AT1G10900, a gene coding for a phosphatidylinositol-4-phosphate 5-kinase family protein, is segregating for a stop codon in both Iceland and Germany.
Each pair defined on the basis of VRNH1 structure was polymorphic for VRNH3 (Table 2), as defined by single nucleotide polymorphisms (SNPs) in intron 1, as reported previously [ 20], and by indels in the promoter region [ 23].
Human populations are polymorphic for risk factor mutations predisposing to diseases and cancer.
* IN22C+ population is polymorphic for this trait.
The structural gene (19q13.2) for apoE is polymorphic with two single nucleotide polymorphisms (SNPs) within the coding region resulting in three different alleles (ε2, ε3, ε4) and six apoE genotypes (three homozygotes ε4/ε4, ε3/ε3 and ε2/ε2, and three heterozygotes ε4/ε3, ε3/ε2, ε4/ε2), each showing different receptor-binding abilities [ 3, 4].
Contingency genes were polymorphic within single colonies, and the observed complex peak profiles suggested a frequency of slippage several orders of magnitude higher than reported for other organisms.
Biasing selection of sites to those that are polymorphic within a single population is analogous to having larger sample sizes for that subpopulation.
TR: Given that more than one gene has to be polymorphic to produce such conditions, I would think they'd be more uncommon than single-gene disorders.
Although most of the nine ALDH genes are polymorphic, ALDH2 is the single genetic factor that most strongly correlates with the incidence of alcoholism in humans.
Thus, 60% of the SNPs tested and 82% of those that amplified a single product shorter than 500 nt were polymorphic and useful for mapping.
