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Because Set2 is linked to transcriptional elongation (Krogan et al., 2003), differentiation genes in GSCs might be poised for expression, but may be kept awaiting bam expression for full activation.
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Similarly, specific histone modifications may distinguish actively expressed genes from genes that are poised for expression or genes that are repressed in different kinds of cells.
Many genes in stem cells are poised for expression with initiated RNA polymerase II at the promoter.
PolII levels at genes that escape inactivation correlate with the levels of their expression; however, additional PolII sites can be found at apparently silenced regions, suggesting the possibility of a subset of genes on the Xi that are poised for expression.
It has recently been proposed that pluripotent embryonic and pluripotent germline stem cells possess an open chromatin structure, and many functional and tissue specific genes in the genome are poised for expression [14].
These TSS clusters may represent genes that are poised for expression upon specific signaling.
Binding of PolII was also detected on 17% of these genes in HSPCs, suggesting some were poised for expression.
Two simple benches are poised for reflection.
Such genes would already reside in the appropriate transcription factory facilitating low-level expression and would be poised for rapid activation in haematopoietic cells.
Thus, genes that are bound by SYT-SSX2 but whose expression is unaltered may be poised for activation in response to certain signaling events.
Thus, competent sponge larvae appear to be poised for rapid and widespread transcription upon settlement, with multiple mechanisms in place to control changes in gene expression.
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