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Besides their allatostatic activity, these peptides appear to be pleiotropic in function [114], [115].
Besides the allatostatic activity of these three groups, which is confined to a specific insect order (Dictyoptera), they all appear to be pleiotropic in function [ 56, 57].
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Many of these transcription factors are pleiotropic in nature, expressing and functioning in multiple tissues simultaneously.
Thus, most mutations are pleiotropic in vivo, for instance.
Most or all of the genes that are involved in early tooth development are thought to be pleiotropic and have additional functions outside of tooth formation.
A number of conserved FMRP targets have been identified in the well-characterized Drosophila FXS disease model, but FMRP is highly pleiotropic in function and the full spectrum of FMRP targets has yet to be revealed.
Autophagy-related ATG6 proteins are pleiotropic proteins functioning in autophagy and the phosphatidylinositol 3-phosphate-signaling pathways.
The stimulation of the immune system seems to be pleiotropic affecting different cells and functions.
Because such genes may function in many developmental processes, mutations in them are expected to be pleiotropic and thus are discarded in most standard genetic screens.
These proteins have conserved functions across all tissues and therefore may not be pleiotropic.
Considering that IL-10 is pleiotropic functions, further studies are necessary to evaluate the immune state.
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