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For example, an offset of ±1AA resulted in 119 sites that can be phosphorylated, while for ±2AA, it is 22 sites and for ± 3AA, there is only 1 site that is amenable to phosphorylation.
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Serine and threonine are both hydrophilic amino acids that can be phosphorylated while alanine is a hydrophobic amino acid that is not phosphorylated.
A conserved structural motif in kinase domains, which needs to be phosphorylated for full activation of the kinase.
Here we show that MCIP1 can be phosphorylated by MAPK and glycogen synthase kinase-3 and that phosphorylated MCIP1 is a substrate for calcineurin.
These findings demonstrate that T372 can be phosphorylated by cdk1.
While message for RET was identified in all tumor samples, this RTK was found to be phosphorylated in only 54% of AGASACA and 20% of TC samples.
While phosphorylation of Y699 is required for transcriptional activity, three tyrosines located in the transactivation domain can also be phosphorylated and modulate STAT5b activity [ 23].
However, while in S. aureus either Tyr440 or Tyr444 are phosphorylated, the IsdB protein expressed in L. lactis was found to be phosphorylated on Tyr311.
While Hsp90beta was phosphorylated at Ser 226/Ser 255 in untransformed cells, phosphorylation was absent in leukemic cells.
USP15 Ser678 is phosphorylated by ATM, which is essential for USP15 recruitment to DSBs.
Notably, MyoD is phosphorylated during the cell cycle while it becomes acetylated during differentiation.
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