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Although Su fu) has been shown to be phosphorylated in response to Hh, how this phosphorylation is regulated remains unknown.
These results suggest that, although additional Hsf1 residues appear to be phosphorylated in response to heat shock, the observed phosphorylation at S571, T575, S577 and T578 contributes to thermotolerance in C. albicans.
In addition, p53 can be phosphorylated in response to oxidative stress, leading to the formation of p53/Smad/p300 complex, which initiates the transcription of Snail, Twist and MMPs.
Histones can also be phosphorylated in response to several cellular processes.
Indeed, Munc18c has been shown to be phosphorylated in response to multiple agonists in several cell types [31] [33].
Interestingly, an important number of the differentially regulated proteins identified in our study are known to be phosphorylated in response to platelet activation by GPVI and αIIbβ3 [12], [12].
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For example, there is evidence that Sty1 regulates the phosphorylation of Cip2: Cis2 is phosphorylated in response to oxidative stress, and this phosphorylation does not take place in sty1 mutants [ 10].
TRAB1, responsible for ABA regulation, is phosphorylated in response to osmotic stress and by the SnRK2 kinase in response to ABA [ 77].
Consistent with Y660 being phosphorylated in response to LPS, no tyrosine phosphorylation of the Y660F mutant was detected despite similar levels of tagged protein expression.
To determine whether DBD plasma treatment of cells could induce DNA damage, we looked at phosphorylation of H2AX, a histone variant that is phosphorylated in response to DNA damage [39].
TRF2 is phosphorylated in response to DNA damage and this phosphorylation has been implicated in DNA double strand break repair [ 36, 37].
More suggestions(15)
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