Sentence examples for be perturbed by mutation from inspiring English sources

Both processes might be perturbed by mutation of the R561 residue that localizes to the β11-loop of the FHA domain.

Thus, cellular systems maintain homeostasis partly by ensuring that processes do not depend on any single component, which could easily be perturbed by mutation or environmental effects, setting the scene for synthetic lethal interactions [4,11,13].

Recently, PDGF receptor signaling was shown to be perturbed by mutations within the activation loop of PDGFR-α in a subset of wild-type c-kit expressing gastrointestinal stromal tumors (GISTs) [ 13].

The present study concerns the means by which polymerization is perturbed by mutation: the relative contribution of specific effects on the underlying structural mechanism and non-specific effects on protein stability.

In this work, we analyzed genomic alterations in cancer cell lines by considering which interactions in the signaling pathway were perturbed by mutations.

In addition, we studied whether these activities were perturbed by mutations in OPA1 that cause DOA.

Also unknown is how sex differences at the protein level are perturbed by mutations that lead to intellectual disability (ID).

Thus, the dynamic behavior of a genetic network cannot be described if it is perturbed by mutations (e.g. tumors) or external factors (e.g. chemicals).

Possibly, an interaction with another protein that plays some part in recruiting dCPAP to centrioles might be perturbed by these mutations.

We did not detect this translocation event in any of our tumors due to our sample size, however we did detected a novel TCF7L2 (G424E) mutation in one of our tumors, suggesting that this gene can be perturbed by multiple mechanisms.

In theory we should still be perturbed by Weimar Germany's decadence and lurking fascism.