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Analysis of primary and secondary endpoints will be performed using relevant significance tests (e.g., chi-square, t-test or analysis of variance).
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qRT-PCR was performed using relevant primers and qRT-PCR kit (TransGen) on a quantitative 7500 PCR system (ABI).
A literature search was performed using relevant search criteria (June 2014).
PCR for mecA was performed using relevant published sequences and temperature parameters [ 17].
Sensitivity and specificity, negative and positive predictive value calculations were performed using relevant specialists as "gold standard".
Second, an automated multivariate step-GAM analysis with forward selection and backward deletion was performed using relevant covariates from the univariate tests that were available in almost all MCI patients, i.e., MMSE, ADAS-cog, FAQ, Trail B test, CDR-SOB, ventricular, and hippocampal volumes.
Because the doses we used in the present study are much higher than the doses infants may be exposed to (~ 10−5 M vs. ~ 10−9 M), further research should be performed using doses that are more relevant to human exposure.
We caution that for priority setting in an individual country, more rigorous comparisons should be performed, using more comprehensive models and considering all relevant vaccines and delivery strategies.
To demonstrate the usefulness of dbWFA, several biologically relevant queries that can be performed using the current system are presented.
To demonstrate the utility of PED, we present several biologically relevant queries that can be performed using the current system.
A total risk characterization is performed using all relevant toxicity data and a comprehensive exposure evaluation in association with the genotoxicity data.
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