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In future work, the Japanese version of EORTC QLQ-HCC18 should be performed in multicenter facilities to confirm the generalizability of the findings and to increase the number of liver transplantation groups and more severely ill patients.
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We studied whether this relatively complex approach could be performed in a multicenter clinical setting.
Studies on determinants and perinatal outcomes of near miss that address these limitations need to be performed in future, preferably prospective multicenter study carried out over a period of two years or more to generate more stable estimates.
A prospective multicenter cohort study will be performed in the south of The Netherlands.
This study is designed as a multicenter, double-blind, placebo-controlled, randomized controlled trial to be performed in patients with colorectal ACF.
METHODS: A prospective cross-sectional analysis of 314 eyes (314 subjects) with intermediate AMD was performed in the multicenter Age-Related Eye DiseAncillary SDOCT StudyAncillary SDOCtoStudy to correlate hyperpigmentary changes on color fundus photographs (CFP) with abnormal morphology on SDOCT.
The study was performed in a multicenter setting with different assessors, which could influence inter-rater reliability.
However, a comparison of their prognostic value has not been performed in a prospective multicenter cohort with clinical follow-up.
Finally, dosing adjustments based on SMBG values could also be made on the basis of the size of the previous mealtime insulin dose, as has been performed in a randomized multicenter study by Bergenstal et al.
As a next step, the quantitative determination of a threshold between responders and nonresponders is currently being performed in a clinical phase III multicenter study (PreCePRA NCT01864265).
Methods: Two identically designed, double-blind, vehicle controlled, parallel group multicenter studies were performed in the United States to evaluate the use of ciclopirox nail lacquer to treat mild to moderate toe onychomycosis caused by dermatophytes.
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