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The age analysis can be performed at: https://dnamage.genetics.ucla.edu/.ucla.edu/
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Blast searches of the H5 and W11 genomes can be performed at http://cracs.fc.up.pt/∼nf/dame/index.html, last accessed March 26 , 2013
GO enrichment analysis was performed at http://bioinfo.vanderbilt.edu/webgestalt.edu/webgestalt
Chi-square tests were performed at http://people.ku.edu/~preacher/chisq/chisq.htm [58] and http://www.graphpad.com/quickcalcs/chisquared1.cfm?Format=C.
The genomic coordinates of the positive CpG islands clones (based on the sequence information retrieved from http://data.microarrays.ca/cpg/) and the −800/+200 regions of the positive promoter clones are supplied in Table S1 GO enrichment analysis was performed at http://bioinfo.vanderbilt.edu/webgestalt with all the 1259 gene id retrieved, but only 1159 were recognized as such.
WebLogo analysis was performed at http://weblogo.berkeley.edu/.edu/
Enrichments were performed at http://bar.utoronto.ca/ntools/cgi-bin/ntools_classification_superviewer.cgi.
Analysis by Phobius was performed at http://phobius.sbc.su.se on complete predicted proteomes.
Enrichments were performed at http://bioinformatics.psb.ugent.be/ATCOECIS using p < 0.05.
Analysis by SignalP2 and 3, and TargetP was performed at http://www.cbs.dtu.dk.dtu.dk
Gene ontology (GO) classifications were performed at http://amigo.geneontology.org with the database filter set as GeneDB S. pombe.
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