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Since recruitment is continuous, the delay in obtaining data on an outcome means that there will be patients at each interim analysis who have been recruited to the trial but who have yet to have their outcome observed.
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Be patient at first.
Be patient at this stage.
A total of 504 patients will be enrolled; eligible patients at each site will be randomly selected using a defined protocol.
In our design, this feature is preserved there are three new patients at each dose level.
Skin biopsy data were consistent between patients at each DL.
Motesanib trough concentrations were similar across patients at each dose level tested, regardless of treatment.
Response was shown for patients at each dose level in Table 4.
Note that not all laboratory parameters could be obtained in all patients at each time-point.
The patients will be asked at each visit for any adverse event (AE) and concomitant medication.
Patients will be questioned at each assessment about side effects, especially hallucinations and nightmares.
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