This is especially important given that hypercoagulability may be particularly harmful in individuals with developed coronary heart disease.
Environmental risk factors such as prenatal exposure to smoking may be particularly harmful in combination with disease susceptibility genes through gene environment (G × E) interactions [ 38].
Although there is emerging evidence that environmental factors may be particularly harmful in combination with susceptibility genes for the disorder, we were unable to document interaction effects between prenatal exposure to smoking and genotypes of the child on attentional control, which is probably because of limited statistical power.
Phentolamine, a potent vasodilator, may precariously decrease blood pressure and hasten haemodynamic collapse in any ICU patient, and would be particularly harmful in a patient with impaired cerebral autoregulation.
According to our previously stated hypothesis, radiotherapy-induced inflammation would be particularly harmful for Any C-carriers with ER-negative tumours, as this inflammation represents an additional inflammatory stimulus that induces Any C-carriers to release large amounts of systemic IL-6, explaining the impaired prognosis among those patients.
For older patients, moreover, longer hospital stays can be particularly harmful, increasing the likelyhood of functional decline with consequent negative impact on quality of life [ 3].
Future epidemiologic studies should include assessments of the synergies among endocrine disruptors, thyroid function, and child neurodevelopment to help better understand these complex interactions and identify OC-mediated effects that may be particularly harmful in cases of decreased thyroid function, with plausible adverse consequences on future neurodevelopment.
Nor is it thought to be particularly harmful to adults, though there have been reports of an association with Guillain-Barré syndrome, an auto-immune condition that causes paralysis.
The proposed cuts would be particularly harmful to the construction industry.
The change "would be particularly harmful to the banking industry (in case he gets a question)," Mr. Piscitelli wrote.
