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It appears likely that such combination strategies will be particularly constrained in effectiveness in those with stage 3 CKD or worse (creatinine clearance <60 calculated by Cockroft-Gault equation and adjusted for ideal body weight).
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This conception comes to life in the rules for editing articles, which, in certain cases, are perceived to be particularly constraining.
Estimates of dN were also lower in conifers than in angiosperms (0.0492 and 0.2019, respectively), but the difference was not as dramatic as for dS (see Table 1, Figure 1.A), suggesting that substitutions at synonymous sites are particularly constrained - or that those at non-synonymous sites are less constrained, at equal mutation rate, in conifers as compared to angiosperms.
These decisions are complicated for people, and the choices for women are particularly constrained.
Young British workers are particularly constrained by the lack of opportunity to work more hours.
Female California sea lions (Zalophus californianus) are central-place foragers and are particularly constrained while provisioning their young.
That's probably because our choices are particularly constrained on the road - in general, all we do is aim to go in a specific direction, in single file, at the speed of our choosing.
In densely populated cities where land is scarce, such as New York and London, supply is particularly constrained, so bubbles are also more likely.Fixed but adjustableSome past housing-market forecasts have come badly unstuck because of economists' tendency to concentrate on demand and ignore supply.
One reason is that when a French government from one side of the political divide has to "cohabit" with a president from the other (as has now happened three times since the Fifth Republic was established in 1958), it is the foreign ministry that is particularly constrained.
Scaling up of weather index insurance pilot projects is particularly constrained by high-basis risk, related to the divergence between the calculated weather index and actual productivity loss on the farm.
A widespread BPHS delivery mechanism in conflict-affected settings, where government capacity and resources are particularly constrained, is contracting of non-state providers to manage service delivery [ 17– 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com