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The resulting protein, containing an internal deletion, would be partially functional but expected to lead to a milder, Becker muscular dystrophy-like phenotype.
The results suggested that the particular CLOCK truncation might be partially functional in protecting from premature aging, at a condition that the intrinsic period is far from optimal.
Thus, it is unlikely that off target RNAi is occurring and we sought to test whether the protein produced by the truncated nhr-64 gene may be partially functional.
Exon skipping technology takes advantage of the fact that internally deleted dystrophins, often seen in BMD, can be partially functional.
Such mutated mRNAs thus encode C-terminally truncated polypeptides, which can in some cases still be (partially) functional.
Exon skipping aims to moderate disease progression by taking advantage of the knowledge that internally deleted dystrophins (seen in BMD) can be partially functional [Béroud et al., 2007; Aartsma-Rus et al., 2009; van Ommen and Aartsma-Rus, 2013].
Similar(51)
These results suggest that Chk1D469G is partially functional while D469A represents a loss-of-function allele.
In the new app, there's now an invitations feature that's partially functional for now.
This state corresponds to the relay mode of operation in which the SN is partially functional as defined in Section 1.
At position 100 a hydroxyl group was required since T100V was inactive, T100C was partially functional and T100S (a conservative substitution) had almost wild-type activity.
Since it has been reported that the GFP-FliG and GFP-MotB fusion proteins are partially functional [9], [10], we fused pHluorin to the N-termini of FliG and MotB to produce Salmonella pHluorin-fliG and pHluorin-motB strains, respectively.
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