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Regulation of EIF4E mediated translation is an important target for therapeutic intervention in light of the fact that EIF4E has been shown to be overexpressed in several cancers and that overexpression can cause malignant transformation of rodent fibroblasts [ 35].
Recently, Wave2 has been found to be overexpressed in several human tumors, and this overexpression correlates with invasiveness of the tumor and poor prognostic for the patient [36] [38].
DR5 has been shown to be overexpressed in several types of cancer including colon, lung and cervical cancer [5] [9].
POSTN was found to be overexpressed in several human cancers including ovarian [28], [30], colon [29], pancreatic [25], [27], breast [31], [32], lung cancer [33], and melanoma [34], with contradictory data concerning the identity of periostin-expressing cells (i.e. stroma, tumor cells or both).
6 Axl has already been reported to be overexpressed in several human cancers.
Bmi-1 was shown to be overexpressed in several human breast cancer cell lines.
Similar(21)
For instance, COPS5 is overexpressed in several tumor types [27], [28], and its overexpression is associated with short disease-free and overall survival in lung cancer [29], [30].
The ERBB2 gene is overexpressed in several human tumors, mostly in breast and ovary carcinomas, where the overexpression is a marker of poor prognosis [ 2].
Casein kinase 2 (CK2) is overexpressed in several types of cancer.
The DEK nuclear protein is overexpressed in several types of human bladder cancer, where it is involved in chromatin reconstruction, gene transcription and apoptosis.
Galectin-3 (Gal-3) is a carbohydrate binding protein that is overexpressed in several types of cancers, including pancreatic cancer, which makes it a good target for both imaging and therapeutic drug design.
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