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Single-cell dormancy is a phase of prolonged cell cycle arrest that can be overcome upon cell-autonomous genetic changes or alterations in the microenvironment.
On the contrary, both high doses of doxorubicin and nutlin-3a promoted quiescence, a reversible cell cycle arrest that can be overcome upon the removal of the triggering stimulus.
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This resistance is overcome upon biolistic or Agrobacterium-mediated inoculation.
This may indicate an inhibition of physiological processes that is overcome upon extended incubation.
These data support a large temperature dependent barrier to the closed state that is overcome upon increasing temperature and a stable closed state once the transition has occurred rather than a pronounced temperature dependence of the equilibrium states.
And yet, despite the drawbacks, which can be overcome and improved upon, J-Street launched onto the Washington scene with a bang.
As others have shown, some of these technical challenges can be overcome by designing RAs based upon multiple reference sequences [20], [21].
These findings show that the failure of Dgcr8−/− ESCs to silence self-renewal upon differentiation can be overcome by promoting either EMT or apoptotic programs and suggest that let-7 silences ESC self-renewal at least partially by activating these programs.
These problems could be overcome.
This can be overcome.
Things can be overcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com