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This challenge might be overcome by simultaneously inhibiting several oncogenic pathways; 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of heat shock protein 90 (Hsp90), accomplishes this.
This suggests that the coactivation of multiple RTKs in cancer cells confer resistance to single-agent therapy, but this resistance can easily be overcome by simultaneously inhibiting several RTKs with rationally chosen drug combinations.
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This limitation could be overcome by the use of integrated PET/MR systems able to simultaneously acquire MR and PET images.
It is demonstrated that this can be overcome by combining physiological artifact filtering and detection of BOLD-related signal changes simultaneously.
The limitations of crystallographic analysis can be overcome by advanced NMR spectroscopy, which makes it possible to study multiple protein conformations simultaneously, over time scales ranging from picoseconds to milliseconds.
Next, we addressed whether syt and cpx-I simultaneously bind SNAREs and whether cpx-I-mediated inhibition can be overcome by Ca2+-syt (as proposed in refs (4 −(6) and (8)).
Fragility could be overcome by toughness.
This could be overcome, by updating agricultural methods.
But several obstacles must be overcome by spring.
This can be overcome by RFID technology.
This could be overcome by tissue engineering.
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