This barrier can be overcome by using model calibration.
LIMITATIONS imposed by human subject research can be overcome by investigating models of human disease in experimental organisms.
The experience from other countries shows that, in principal, the fractionation of palliative care can be overcome by new models of care.
The limitations of biological experimentations in this system can be overcome by computational modelling, which is proving to be a valuable tool to shed light on the function of not only this system [ 35- 37], but other signalling networks too [ 38].
The question is whether these physical constraints can be overcome by modifying the model to include funding and paid project leadership to guide volunteers (as well as paid employees) through the drug discovery phases.
We noticed a serious knowledge gap in understanding principles and practices of data management in most of our research sites in LDCs, which can be overcome by implementing the model data management system.
These main shortcomings of simplified analytical procedure can be overcome by using physical modeling and numerical techniques.
This problem can be overcome by exploring empirical models, such as so-called Self-Organizing Maps (SOM).
Discrimination of direct versus indirect effects is a limitation of these experiments however this may be overcome by applying computational models of consensus binding sites generated by CLIP or SELEX to classify global changes in alternative splicing [39], [41].
This can partly be overcome by studying animal models which are representative for the human situation, are highly homogenous and are kept under strictly standardized experimental conditions.
