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Applications of quality by design approach in the fabrication of core-shell nanostructures are presented: by carefully selecting which combinations of the formulation and process variables to evaluate, the properties of core-shell nanostructures can be optimized using statistical design of experiments, followed by computer numerical and graphical optimizations.
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Enzyme production was optimized using statistical approach.
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Process conditions were optimized using statistical experimental design methodology.
The derivatization conditions were optimized using statistical experimental design and multivariate data analysis.
Low-cost medium component for fermentation and the down-streaming process for intracellular astaxanthin production by Phaffia rhodozyma MTCC 7536 were optimized using statistical methods.
Furthermore, a methodology to maximize the production of a prime N-alkylamide, Deca-2E,6Z,8E-trienoic acid isobutylamide (spilanthol), from in vitro cell cultures was optimized using statistical tools.
The culture and nutritional parameters associated with unoptimized LM10 medium were optimized using statistical approach to maximize the recovery and enumeration of endolithic bacteria.
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Immobilization yield was optimized using a statistical method, central composite design.
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