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However, differences in gene expression between neuronal cell types are likely to be relatively small, so both the experimental protocol and the subsequent analysis had to be optimized to detect small, but consistent, differences in gene expression.
All algorithms seem to be optimized to detect exon skipping events, while of the three types of splicing investigated, variable length exons present the greatest challenge.
In GMO risk assessment, the protocols must be optimized to detect side effects, in particular for herbicide-treated GM plants.
Serologic techniques also can be optimized to detect incursions of novel viruses such as the highly pathogenic Eurasian H5 viruses (10 ) among wild birds.
Second, the signature patterns derived from ES cell differentiation following LIF removal may not be optimized to detect DMSO-induced cell differentiation.
Genotyping methods can be optimized to detect better whether there is a preferentially active AR allele by either genotyping tumor tissue or serum DNA using methylation sensitive enzymes [ 72].
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The detector is optimized to detect the slow recoil protons from deeply virtual Compton scattering.
Typically, metabolomics uses non-targeted methods where the analytical conditions are optimized to detect and identify as many molecules as possible.
Presented is a CMOS photodiode structure that is optimized to detect green light, the peak emission wavelength of commonly used fluorophores and other luminescent probes.
Many of those strengths and limitations are relevant to user interface design, such as the vision is optimized to detect contrasts (edges), not absolute brightness; the ability to distinguish colors depends on how colors are presented; some people have color-blindness; and the user's display and the viewing conditions affect color perception.
We did notice, however, that this algorithm systematically detected deletions located in sub-telomeric regions for both tumors and controls, which indicates a systematic bias and suggests that the algorithm is optimized to detect duplications and amplifications but not deletions.
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