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Targeting of this SNP allows detailed study of how guide strand anatomy can be optimised for single nucleotide specific silencing and whether this could form the basis of a potential therapy for SCA7.
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In this study we have systematically studied RNAi hairpin design and how hairpin guide strand anatomy might be optimised for discriminating single nucleotide mismatches in the atxn7 gene.
Secondly, the network should not be optimised for any particular application.
'We think of the organisation as a system to be optimised for all stakeholders,' said John Mackey, of Whole Foods Market.
Aerials can therefore be optimised for the backscattering signal.
The tests demonstrated that each imaging modality needs to be optimised for this particular application: it is, in general, not sufficient to repurpose an existing device without modification.
The components to be optimised for mate selection are underlined.
The overall contrast can also be optimised for each image.
Instrument setting was optimised for each single analysis [19] looking for "compromise" conditions ensuring the best analysis quality by all the three detectors.
The code has not been optimised for speed and is only single threaded within the KNIME framework, so one can expect significant performance enhancements in a production version of the system.
Next, the design of the pieces of this material, used in high-speed rail fastenings, is optimised for fatigue efforts by means of accelerated single-piece tests.
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CEO of Professional Science Editing for Scientists @ prosciediting.com