Guitar Center "is optimally positioned for a sale, given its dominant competitive position and capital allocation opportunities, as well as a savvy shareholder base that is likely increasingly weighing in with the board and management," said Goldman Sachs analyst Matthew Fassler on May 30.
In the active conformation, all key catalytic residues are optimally positioned for catalysis, and two conserved networks of hydrophobic "spines" are aligned.
In addition, Lys117 and Lys147 were just the two residues on the interface binding pocket of HRas with Ras-specific GTPase activating proteins (RasGAPs, or GAPs), and GAPs, which supply additional catalytic residues ('arginine finger') such that a water molecule is optimally positioned for a nucleophilic attack on the gamma phosphate of GTP, hydrolyze a bound GTP molecule into GDP.
EBs appear therefore to be optimally positioned to sense nucleotide hydrolysis-dependent structural changes in the microtubule lattice.
Unfortunately we do not have data on lead position, nor on whether the leads were considered to be optimally positioned which has been reported to be important.
Indeed, in the MCC crystal structure, a Mad3 KEN box is optimally positioned by Mad2 to obscure the recognition sites for the KEN box degron on Cdc20, providing support for the pseudosubstrate model (Chao et al. 2012).
The flowering of the Bay Area cabaret scene ultimately suggests an enduring hunger for the close-knit exchanges with performers that the format is optimally positioned to provide.
They are optimally positioned and not collocated.
