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In clinical trials, compliance is likely to be optimal owing to the close monitoring of patients and the volunteer nature of such studies (Osterberg and Blaschke, 2005).
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However, the values of other genes are not ideal but optimal owing to the less weight to their objective functions.
The superiority of the efficacy of AIs over tamoxifen observed in clinical trials, where compliance is likely to be optimal (Osterberg and Blaschke, 2005), may be diminished in real life owing to differential non-compliance rates.
It's too large a currency area to be optimal.
While potentially the optimal strategy for handling inbound leads, these methods are unlikely to be optimal for handling outbound leads.
Those fees may well be too low to be optimal.
How big has this re-direction actually been in relation to what might be optimal?
Autumn is optimal time to enjoy the city's natural landmarks.
There are optimal routes to sail across an open sea, as there are optimal routes to walk across open land.
"Consistently sleeping six to eight hours per night may be optimal for health.
CMF regimen was recommended to all of eligible patients recruited before 2002, while anthracycline-based regimen including cyclophosphamide, epirubicin, and 5-fluorouracil (5FU /cyclophosphamide, adriamycin, and 5-fluorouracil (CEF/CAF) was optimal for participants after 2002 owing to real superiority relative to CMF based on several randomized-control trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com