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The existence of males and females was discussed by Ford as a prime example of a balanced polymorphism because, "It is obvious that any tendency for the males to increase at the expense of the females, or the reverse, would be opposed by selection" (Ford 1975, p. 111).
However, this molecular drive will be opposed by selection for genome functions, especially optimal protein coding.
TEs will inevitably create an upward pressure on genome size, though this might be opposed by selection at the organismal level (for metabolic and or regulatory efficiency).
Similarly, a seminal review on "developmental constraints" [ 54] suggests that developmental biases on the "production" of variation might bias evolution, but argues that this would be consistent with population genetics only if we allow the changes to be neutral, as otherwise they would be opposed by selection.
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This tendency is opposed by selection, which amplifies fit individuals on the right, while decreasing the number of unfit individuals on the left.
Nonetheless, given the sheer number of introns in many metazoan genomes reaching 200,000 in human and other vertebrate genomes the proportion of introns whose loss is opposed by selection remains very much an open question, with answers ranging from a small minority to a clear majority still being well within the realm of possibility.
Because of its obvious negative impact on organismal fitness, it should be opposed by natural selection.
However, local adaptation driven by strong directional selection may be opposed by negative frequency-dependent selection (NFDS), where rare morphs are favoured, generating cyclical changes in morph frequencies over time [ 18– 20].
Pheromone signaling systems are described as "highly canalized" because changes in production or response are opposed by strong selection against novel phenotypes [ 5, 6].
Cancer is one large class of such multicellular deregulation often resulting in death [ 1], and poses the puzzle of how or whether it is opposed by natural selection.
However, mean group fitness is a declining function of mean zi and is opposed by among group selection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com