Similarly, in obese diabetic (ob/ob) mice, GIP, GLP-1, and (Abu8 GLP-1 displayed substantial glucose-lowering and insulin-releasing activities, whereas (Abu2 GIP was only weakly active.
The first variant was only weakly active, had molten globular characteristics, and was monomeric at 25 °C despite being based on nearly all dimeric enzymes.
The juices from watermelon, blackberry, strawberry, black currant, and Red delicious apple showed moderate suppression, whereas sour cherry, grapefruit, red currant, and pineapple juices were only weakly active.
Somewhat surprisingly, compound 26 was only weakly active in vitro against mouse and monkey tumor cell lines even though it was a potent inhibitor of NAMPT enzymes derived from these species.
Interestingly, both QC and CPZ are only weakly active in the yeast-based assay, which contrasts with GA.
However, under other circumstances Sp3 is only weakly active, and in some cases, Sp3 can repress transcription driven by Sp1 or other transcription factors [32].
In contrast, gabapentin was only weakly active against Freund's complete adjuvant-induced mechanical hyperalgesia [ 25, 26].
Our compounds show potent activity at low doses whereas 2MeOE2 at the same low dose is only weakly active.
For decades, arsenic has been considered a nongenotoxic carcinogen because it is only weakly active or, more often, completely inactive in bacterial and mammalian cell mutation assays.
