However, the affinity of HPr9 30 for EIsc was only moderately lower than that of EIsc for HPrsc, suggesting that this peptide could be considered a promising hit compound for designing new inhibitors against the PTS.
In addition, ADAR1 expression was only moderately lower in hESCs versus the cortex while ADAR2 expression was significantly lower (Figure S4).
Under these conditions formation of nitrosating species in the gas phase and rediffusion into the solution are prevented, yet GSNO formation was only moderately lower (0.51±0.06 vs 0.87±0.02 µM, n=4, not shown).
Steady-state concentrations of enzalutamide, including the pharmacologically active metabolite N-desmethyl-MDV3100 N-desmethyl-MDV3100 N-desmethyl-MDV3100re only moderately lower than what has been reported in pathents receiving 160 mg/day enzalutamide (Cmax values for enzalutamide and the pharmacologically active metabolite, N-desmethyl enzalutamide, were 16.6 μg/ml and 12.7 μg/ml, respectively).
The predictive accuracies the reviewers mention (from Figure 7) are only moderately lower than that obtained for typical midget cells (e.g. Figure 3C); that difference may be due to the relatively stronger increment-decrement used for evaluating the model, compared to the white noise used to train it, as is now suggested in the text.
Surprisingly, given the large evolutionary distances between D. mel and the other insects for which we predicted CRMs, the observed success rates are only moderately lower than what we have previously demonstrated for using Drosophila training data to predict CRMs in the Drosophila genome.
The expression levels of IL-8, IL-1β, IL12 p40 and K60 in C. glabrata infected embryos 24 p.i. were only moderately upregulated and lower than in C. albicans infected embryos (Fig. 5E).
Additionally, the DnaJs, which activate Hspa ATP hydrolysis, are only moderately expressed in the forebrain and exhibit lower levels of expression in the other regions.
ABT-737 treatment alone was only moderately effective at killing melanoma cells at 10 µM for 48 h, and ineffective at lower doses (Fig. 1A).
They found that the happiest individuals went on to have lower levels of income, academic achievement, job satisfaction, and political participation than did people who said they were only "moderately" happy earlier in life.
