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Defects in von Hippel-Lindau (VHL) tumor suppressor gene function appears to be one key event in clear cell RCC, in both hereditary and sporadic cases [ 2].
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Thus, the disruptions of neuron oligodendrocyte interactions and ion channel localization/expression at and near nodes may be one key pathogenic event in MS, especially during the early stage of the disease.
Hidden among the 70 or so announcements Amazon made at today's big Alexa event was one key hidden presence.
There's one key difference.
Unionization is one key approach.
Our results demonstrate that PI-3K/Akt mediated PI-3K/Akt mediatedon is at least one key event implicyclinin the arsenite human skin carcinogenic effect.
This process must be tightly controlled and in S. cerevisiae one key event is the Rtt109-mediated modification of histone H3 by acetylation of lysine 56 (Han56) (Han et al., 2007; Driscoll et al., 2007).
Identification of several mutations in the TLS gene from ALS patients suggested that disruption of RNA metabolism might be one of key events in ALS pathogenesis.
In addition, while no mode of action is strictly sequential, it is clear that a progression from one key event to another is necessary to provoke a carcinogenic response from chloroform.
An analysis of dose-response concordance should enable the identification of a rate limiting key event for the MOA and whether any one key event is the critical determinant of the response.
One key event promoting early autophagosome formation is the RalB-mediated formation of Beclin1/Exo84 complexes [ 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com