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Nevertheless, our observation that three residues (Tyr 3, Thr 47 and Cys 54) are in a chemical environment that differs from that in the visible state both in the "thermal" and in the CEST-detected exchange partner raises the possibility that these states are not completely independent and may even be on the same pathway.
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We have shown that btg and rblA are on the same pathway controlling preference for ALC fate.
Therefore, it is clear that these two forms of oxidative stress cannot be used interchangeably nor their effects interpreted as being on the same pathway in studies of aging or oxidative damage.
Additional adjustment for BMI to explore residual confounding showed weaker nonsignificant associations, but it is questionable whether inclusion of BMI represents overadjustment because BMI and sex hormone levels are on the same pathway.
Historically, over-representation analysis (ORA) was the first method applied, which statistically evaluates the fraction of genes (e.g. all significantly over-expressed genes in a certain disease entity) in a particular biochemical pathway and compares it to a background distribution (e.g. all screened genes in the study that are on the same pathway).
We suspect a complex relationship between the exposures studied here, some of which may be on the same causal pathway for early death.
This SMC degeneration resembles that of Srf deficiency suggesting that both SRF and Dicer may be on the same regulatory pathway of SMC differentiation and survival.
Thus, it is not surprising that BMI may act as an important confounder in the association between SRH and T2DM in this study—or as a mediator since SRH and obesity might be on the same causal pathway.
Nevertheless, even if these two environmental events are part of a pathway to adult MS, they may not be on the same or the only pathway.
"The patient had a mutation in one gene that was right on the same pathway as the therapy," Dr. Baselga said.
We're still on the same pathway as we began.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com