ISSUE: Catheter-associated urinary tract infection (CA-UTI) is a high-volume nosocomial infection that is of significant consequence to the hospitalized patient in Japan and contributes to the development of antibiotic resistance in the hospital.
Lawmakers have called for state and federal investigations into the case, and any findings could be of significant financial consequence to both the utility and the transportation authority.
This observation is likely of significant consequence to the platforms used in our tolerance induction model, since uptake of the particles and cross-presentation of the covalently linked antigen onto MHC class II molecules of recipient APCs is necessary to promote T cell anergy via the two-signal hypothesis.
As new drugs have been designed to manage disorders that are uncommon, but of significant consequence, they may have adverse effects that are acceptable only because they are so uniquely beneficial to these specific conditions.
However, for Rab GTPases, if the catalytic glutamine residue is supplied by the GAP protein, one cannot assume that such a mutation will be of any significant consequence in cells, since a GAP protein may still be able to inactivate this enzyme.
But from a rugby point of view, and from the point of view of the competition, this is an issue of significant consequence.
So there is really nothing of significant consequence to this courtroom skirmish, though it does highlight the potential that a significant minority of Elan's shares could still remain outstanding after Royalty Pharma's acquisition.
It is a day acknowledging an issue of significant consequence to our society, while also claiming the territory of "we can do something".
