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Certainly, PI control of study design would seem to be of questionable applicability in cases where the design of the study is determined in advance by explicit regulatory agency direction.
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This makes studies of older designs sometimes of questionable applicability to those currently being sold.
However, health care providers are often faced with a paucity of evidence for specific patient groups such as children and youth, and thus must rely on evidence of questionable applicability as the basis for their health care decisions.
The first method is of questionable value.
However, your articles were of questionable taste.
CTCs are of questionable utility in non-metastatic prostate cancer.
"But it is of questionable good safety...
Many of these are of questionable quality.
Commonly identified flaws in reliability studies are the exclusive use of healthy individuals, questionable applicability in clinical practice, low sample size, the absence of a protocol and the use of inadequate statistics [ 18].
Commonly identified flaws in these reliability studies were low sample size, unclear selection criteria, the use of only healthy individuals, use of inadequate reliability statistics, the absence of a protocol, and questionable applicability in clinical practice.
This unclear status and the subsequent questionable applicability of existing federal guidelines for human subject research pose an ethical concern.
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