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Apart from good responsiveness, an outcome measure should be of proven validity and reliability, and should preferably be inexpensive and easy to administer.
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GHQ-12 is of proven validity internationally [ 13].
Other individual marker genes have been found of proven validity in this field, such as α-methylacyl coenzyme A racemase (AMACR) [20], [21] or Prostate Cancer Antigen 3 (DD3/PCA3) [22], but at the moment no relationship between the expression level of PCA3 and tumour grade or staging was found yet.
Thus, the comparison between a recently developed assessment tool and one of proven validity is an adequate strategy for determining the quality of the former.
It is of proven reliability and validity [ 16, 17].
In addition, the lack of antiparasitic activity of these potent inhibitors of Leishmania CRK3 suggests that genetic studies alone are insufficient to prove validity of Leishmania CRK3 as a drug target; chemical validation is also required.
To prove validity of in vitro findings, germ-free mice were monocolonized with F19.
The K10 proved to be of good validity with an AUC of 0.806, while the AUC of the K6 is only marginally lower.
The only thing that can ever be proven is the validity of strings of characters we use as passwords and keys.
The aim of this work is to prove the validity or limitations of these formulas for various combinations of dusts and gases.
Instead, Singer says, the main aim of the current work is to "prove the validity of thermodynamics in the single-atom regime".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com