Sentence examples for be of prognostic impact from inspiring English sources

In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested.

To unravel the underlying molecular alterations of ETP-ALL as a specific T-ALL subgroup, we studied the expression of candidate genes reported to be of prognostic impact.

In neuroblastoma (NB), the most frequent solid extracranial cancer in childhood, characterised by substantial clinical heterogeneity, several recurrent genetic alterations have been shown to be of prognostic impact (Maris et al, 2007; Janoueix-Lerosey et al, 2010; Maris, 2010).

Furthermore, the presence of several genetic copy number alterations observed recurrently in NB tumors (deletion of 1p, 3p, 4p, and 11q and/or gain 1q, 2p, and 17q) have been shown to be of prognostic impact 2. Despite the extensive description of copy number alterations in NB, few single gene alterations have been shown to be driver mutations in NB oncogenesis.

A large number of these segmental alterations have been shown to be of prognostic impact in univariate analyses (Maris et al, 1995; Caron et al, 1996; Schleiermacher et al, 1996; Bown et al, 1999; Spitz et al, 2003, 2004; Attiyeh et al, 2005; Pezzolo et al, 2009; Jeison et al, 2010).

In conclusion, the genomic profile is of prognostic impact in patients without MYCN amplification, making it a help in the management of low-stage NB.

We furthermore sought to determine if a segmental genomic profile is of prognostic impact in this cohort, especially in patients without MNA.

Genomic profiles provide a comprehensive overview of genomic changes in NB and are of prognostic impact in patients without MYCN amplification, making them a help in the management specifically of low stage tumours.

Despite its much higher resolution, FISH on interphase nuclei using a panel of probes covering the most frequent genomic inbalances seen in CLL still cannot replace classical cytogenetics, which is superior in detecting complex karyotypic alterations that are of prognostic impact.

The DNA index was not of prognostic impact in this study using previously published cutoffs.

The DNA index was not of prognostic impact in the studied population.