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For most participants, physical aspects of addiction do not seem to be of primary relevance.
Several kinases are known to activate and sustain SAC, and cdk1 itself appears to be of primary relevance.
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The navigational access is of primary relevance for in-memory implementations, whereas declarative access is important for database support.
The impact of ENMS on plants as central component of ecosystems and worldwide food supply is of primary relevance.
Understanding the mechanisms of the interaction between a protein surface and its outer molecular environment is of primary relevance for the rational design of new drugs and engineered proteins.
Therefore, both nucleosome dynamics as well as local changes in chromatin organization, including introduction and/or removal of covalent DNA and histone modifications, at genes with a key role in cell proliferation, are of primary relevance.
Although we agree with the authors that it is quite difficult to delineate the role of depression and anxiety in cases of burning mouth syndrome [7], we did not think these psychiatric factors were of primary relevance in our case as there was no history of such.
These latter analyses are of primary relevance to examining olfactory mechanisms of inbreeding avoidance.
The distinction between our position and that of Forterre that is of primary relevance for the conclusions of this study is the adoption of different scenarios for the origin of eukaryotes.
In this subset of patients, a palliative treatment is a reasonable option and a careful evaluation of the therapy-related toxicity is of primary relevance in the selection of the appropriate chemotherapy regimen.
Another important factor is remaining life expectancy (Ko and Sonnenberg, 2005; Lin et al, 2006), which is of primary relevance for a potential upper age limit for CRC screening.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com