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As there was no known EGFR copy number threshold value that might be of predictive utility in this setting, a series of models with different stringencies were designed to provide definitions, which could be used to assign FISH status (Table 1).
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In principle, a protein may be differentially phosphorylated but be of little predictive utility for the broad classification of a disease or for devising a personalized treatment strategy.
The aim of this review is to provide an overview of proteomic technologies and how the outcomes delivered by such platforms may be translated into applications of predictive utility in clinical and basic science.
The lack of predictive utility is not a function of low reliability, low power, or insufficient variability between subjects.
Here the notion of predictive utility, in a relative entropy framework, is extended to small random samples by the definition of a sample utility, a measure of the unlikeliness that a random sample was produced by a given prediction strategy.
Therefore, whilst elucidation of the full genetic architecture of insecticide resistance and other medically important traits will likely have to wait until association mapping by whole genome sequencing becomes economically feasible for A. gambiae, major effect variants that will be of greatest utility for predictive diagnostic screening can be identified.
Currently, two randomized prospective trials are investigating the predictive utility of uPA/PAI-1 for newer forms of breast cancer systemic therapies.
Perhaps more notable is the consistent predictive utility of an infant's nutritional status for BCG immunisation delays which accords with available limited reports from other resource-poor countries on default among older infants [ 30, 31].
Most studies were longitudinal cohort designs, allowing for stronger conclusions to be drawn regarding the predictive utility of the constructs under review and most adjusted for pre-pregnancy BMI, a known confounder of GWG [ 1].
Third, concerns have been raised about the predictive utility of murine models of sepsis [ 16].
The purpose of this study was to explore the predictive utility of the Health Action Process Approach HAPAandand test a HAPA-based healthy eating intervention, in adults with type 2 diabetes mellitus.
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