Sentence examples for be of pathological importance from inspiring English sources

In agreement with previous studies, GABAA receptor-mediated inhibitory gain-of-function may be a common feature in models of typical absence seizures, and could be of pathological importance in patients with SSADH deficiency.

Our data demonstrate altered GABAA receptor-mediated inhibition in all three neuron types that may underlie the appearance of absence seizures in SSADH−/− mice and be of pathological importance in human SSADH deficiency.

This finding offered further evidence that FOXP2 is of pathological importance in DVD in the absence of other cognitive disorders, which were exclusion criteria in this study.

In line with these studies, it has been found that an increase in sphingosine and a concomitant decrease in S1P are of pathological importance in the early events of the lysosomal storage disorder, Niemann-Pick type C1.

Thus, the binding of C1q to platelets is of potential pathological importance for immune complex diseases such as SLE and vasculitides.

Further insight into this may be of physiological and pathological importance, and a differential distribution of sensory afferent fibers in the human esophageal mucosa may contribute to special differences in esophageal sensitivity.

Interestingly, different isoforms of versican affect cell behavior differently and could be of importance during pathological progression.

However quantitatively, muscle and red blood cells are probably the main tissues in physiological conditions, but other organs (such as the lung, for instance [ 3]) could be of importance in pathological states.

Since ROS production is increased in many cardiovascular diseases, such process could be of great importance under pathological conditions.

Since histamine mediates a wide range of cellular responses, including allergic and inflammatory reactions, gastric acid secretion, vascular tone and permeability, and neurotransmission in the central nervous system [12], the histamine biological responsiveness may be of special importance in certain pathological aspects suggestive of histamine release.

Thus, at present all patients receiving preoperative chemotherapy must also undergo surgery, so a marker that can predict good response rather than complete pathological response may be of great clinical importance.