Sentence examples for be of moderate affinity from inspiring English sources

The interaction of cargo with a coat component, however, needs to be of moderate affinity (1 50 μM KD) and therefore dynamic, in order that the proofreading of cargo incorporated into CCVs and the dissociation of cargo and adaptors during clathrin cage disassembly can readily occur.

The interaction between these proteins, as determined by surface plasmon resonance, was of moderate affinity (in the order of 1 μM).

In fact, the interaction of AGT WT and Pex5p PTS1 binding domain (Pex5p-pbd) is of moderate affinity (K d ~ 1.5 3.5 μM; [ 30, 48]) and decreases 10-fold for the isolated C-terminal PTS1 octapeptide [ 2, 28].

Peptides of moderate affinity are suggested as analogues for use as competitor against diabetes associated epitopes in class II MHC binding as a means of preventing the autoimmune response.

Bound proteins were eluted sequentially with buffer containing 0.3 M NaCl to remove proteins of moderate affinity, then with 1 M NaCl to elute higher-affinity partners (Figure 1A).

The story, though, is of moderate interest.

Many novel independent sequences were recovered with moderate affinity and high specificity for ATP, validating this scaffold for the generation of functional molecules.

A moderate affinity was chosen in view of toxicity issues with two high-affinity anti-Ep-CAM mAbs (Khor et al, 1997; LoBuglio et al, 1997; Saleh et al, 1997; de Bono et al, 2002), and an otherwise very benign safety profile of the moderate affinity murine IgG2a mAb edrecolomab (Panorex®) (Braun et al, 1999; Kirchner et al, 2002; Punt et al, 2002).

The best improvements in reactivity for the same catalytic domain (~4×) were correlated with broad specificity and moderate affinity of CBM binding.

This moderate affinity is considered to be crucial for allowing transient association and dissociation events in cell signaling.

However, the values of Δπmax were of low magnitude (Table 2), which indicated a moderate affinity of the peptide for these gangliosides compared with GalCer-HFA.