Sentence examples for be of lower methodological from inspiring English sources

Thirdly, trials using surrogate outcomes may be of lower methodological quality than trials using final patient relevant outcomes and therefore more prone to exaggeration of effect size.

First, the smaller trials may be of lower methodological quality: an analysis of 190 trials within 14 meta-analyses, smaller trial were 3 times more likely to be of low quality[ 13].

However, there has also been evidence that studies published in local journals may be of lower methodological quality, as reported by Sterne et al. [ 89], and this would be in favor of their exclusion.

The three trials [ 20, 22, 23] in which the intervention effects favoured nurse-led care were of lower methodological quality (small study (N < 200), lack/unclear random generation and allocation concealment and/or blinding and/or ≥20 % attrition).

Although nurses were in NP roles in 16%% (4/25) of the outcomes that favoured nurse-led care, the studies were of lower methodological quality somehow (lack/unclear random generation and/or allocation concealment and/or ≥20 % attrition and/or small study).

The small trials were more likely to show a benefit for hydration with sodium bicarbonate, but these studies were generally of lower methodological quality.

Third, results derived from a cohort study are generally of lower methodological quality than those derived from randomized trials, because a cohort study design is subject to bias related to adjustments for confounders.

Five studies with the highest rates of PTSD (66.7 to 86 %) were all of lower methodological quality.

One approach to resolving the problem of apparently insufficient evidence may be to assess evidence of lower methodological quality.

We next assessed the effect of trial quality on outcome as it is often hypothesized trials of lower methodological quality tend to yield more positive clinical signals for the therapy being tested when compared to trials of higher methodological quality.

There is evidence that studies of lower methodological quality tend to report larger treatment effects than high quality studies [ 5- 7].