Sentence examples for be of lower affinity from inspiring English sources

A survey of possible 'off target' binding elements suggested that these tend to be of lower affinity and are transcriptionally inert (Fisher et al., 2012).

On the contrary, the circulating serum antibodies may be of lower affinity than those that are tissue bound and thus are more easily washed away during the wash-out step of the assay.

This suggests that any point mutations that might have rendered self-binding to be of lower affinities were either suppressed or eliminated during evolution.

Fluorescence Correlation Spectroscopy (FCS) affinity assays indicated that CaM binding to this site is of lower affinity as compared to the other sites [18], raising doubts on whether it actually binds CaM or merely contributes to CaM binding to BD-C2.

In contrast, sera from adjuvant immunized mice did not reveal kinetoplast binding (Figure 1E, right panel ) indicating that either the anti-DNA antibodies present in these mice were of lower affinity than the anti-dsDNA antibodies obtained from rEBNA-1 injected mice or they were not specific for dsDNA.

Apparently, this alternative complex is of lower affinity than the native receptor complex.

Moreover, the possibility that in the presence of helminth infections, IgE antibodies generated are of lower affinity and therefore can not lead to mast cell degranulation has also been put forward [ 22].

Even upon incubation with TIMP-3, only a small portion of ADAMTS5-5 was retained on streptavidin Sepharose beads, indicating that PPS ADAMTS5-5 TIMP-3 complexes are of lower affinity than PPS ADAMTS5-2 TIMP-3 complexes and dissociate upon washing.

The latter interaction is of lower affinity and occurs poorly in the absence of the concentrating effects that result from the formation of the TFPI complex with factor Xa.

Second, studies conducted in the early 1970s [ 72- 74] revealed that antibodies produced by aged as compared with young mice in response to antigenic challenge were of lower affinity and avidity.

For example, antibodies used in ELISA assays are of lower affinity than those used in immunohistochemical stains since the former type of reaction is a competitive assay and the latter reaction depends upon high affinity binding to survive the multiple steps of processing the tissue section.