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The third conformation, with extended legs and a closed headpiece, is expected to be of intermediate affinity [5].
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For example, the repertoire of TCR response to sperm whale myoglobulin 110-124 in adjuvant is initially diverse, then progressively losing lower affinity clones and resulting in an oligoclonal population of TCRβ receptors of intermediate affinity [ 18].
Some individuals are of intermediate size.
Subtropical cyclones are of intermediate size.
As shown in the Table 2, 87 of the 131 predicted peptides, or 66%, turned out to be high or intermediate affinity binders.
It is of interest that expression of intermediate-affinity LFA-1 at the leading edge of the T cell differs from migrating endothelial cells that display high-affinity αvβ3 in this location (Kiosses et al, 2001).
Riders should be of good intermediate level.
This can be readily explained by the intermediate affinity of catumaxomab to CD3 (KD= 4.4 n m) which does not allow quantitative T-cell binding at very low antibody concentrations.
Given that this step may result from a shift of the intermediate affinity state where the ligand is already bound transiently, integrin signalling via mAbp1 and HPK1 may already be bidirectional at this point.
In addition, the Rac-specific gunanine nucleotide exchange factor P-Rex1 is critically involved in regulating the intermediate affinity of LFA-1.
Natural Killer (NK) cells also require higher concentrations of IL-2 to be activated since this subset primarily expresses the intermediate affinity IL-2 receptor that is composed of dimers of the β and γ chains.
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