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Only the trial by Hall [ 20] did not fulfill at least four criteria and was considered to be of insufficient methodological quality; the other seven trials were of sufficient methodological quality.
Results of the methodological quality assessment of the 10 included trials are shown in table 3. The observed total validity score ranged from 3 to 7. One trial [ 20]did not fulfill over half of the criteria (≥ 5) and was considered to be of insufficient methodological quality.
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Most international studies on reallocation of care to PAs are restricted to primary or critical care, limited to one outcome measure, or are of insufficient methodological quality [ 2].
Two trials were not tabulated, because one was of insufficient methodological quality [ 20] and another presented only a subgroup with poor health from the studied general population of older people [ 8, 9].
However, these findings for frail older persons were based on only four studies, including one nonrandomized controlled trial [ 27] and one we scored in our review as being of insufficient methodological quality [ 20].
The integration of behavior, electrophysiology, and immunohistological data provide convincing evidence that IL suppression through D1 activity is necessary for reinstatement. 1) My primary concern is that there is insufficient methodological detail for the quantification of c-Fos+ cells.
Reviewer #2: 1) My primary concern is that there is insufficient methodological detail for the quantification of c-Fos + cells.
The included trials were of good methodological quality except for the trial by Yildirim et al. 27 Insufficient details were given to enable assessment of blinding at all levels.
Overall, trials were of moderate methodological quality.
Both papers are of good methodological quality.
Four trials were of high methodological quality.
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