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This review not only highlights the need for increased research into the study of multimorbidity or comorbidities of chronic diseases, but also the need for such studies to be of greater methodological rigour, given that almost a third of the studies included in this review scored only 50% using the critical appraisal tool.
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Some limitations identified in the studies are of great methodological importance, for example, a lack of a control group for comparing results.
Importantly, methodological differences may be of greater importance if small bench-top analysers are used.
Therefore, while the record review method and its various adaptations may potentially be of great use, it is essential to first resolve this methodological and statistical challenge.
Nonetheless, we feel that our methodological framework, in general, and particularly the advanced spectral methods used, in particular, may be of great help in future synchroneity studies.
Studies of greater methodological quality are required to accurately assess the impact of community development projects.
The assessment of methodological quality is of great importance to systematic reviews.
8 10 The methodological quality is of great importance, and it is thus critical to assess CPGs for hypertension using a well-defined process.
If, in fact, a true causal association between diet quality and depression exists but is being masked by methodological shortcomings, this is of great clinical and public health significance.
However, it is of great importance to mention that they differ in quality, with some having significant methodological flaws--mainly owing to selection bias and retrospective study design.
As no head-to-head studies of the WatchBP Home A (or equivalent device) and pulse palpation were identified, the EAC made an indirect comparison using data derived from the SAFE (Screening for Atrial Fibrillation in the Elderly) study [ 16], which was considered to be of highest methodological quality and have greatest external validity.
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