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Fast acquisition of P-gp activity by doxorubicin-sensitive MCF-7 in a population of growing tumoural cells may be of first relevance to determine the dynamics of response to chemotherapy.
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These data now conduce one to consider that renal gluconeogenesis substantially participates in postabsorptive glucose production and that its role in adaptation is of first relevance.
It's likely that the latter will have the most wide appeal and, as ever, the £25,000 first prize will be of less relevance than the accompanying critical fanfare.
This aspect may be of higher relevance than obvious at first glance.
This second mechanism may be of particular relevance where siRNA-mediated protein knock-down is not 100% efficient, which is common when utilizing siRNAs.
The first negative control will be of orthodontic relevance but will have no effect on the amelioration of the symptoms of OSA (ie, crowding or impacted canine).
The second negative control will be of relevance to OSA symptoms, but cannot be changed by orthodontic treatment (ie, body mass index or neck circumference).
How can such detail not be of relevance?
In order to provide evidence that predicted C-terminal TMDs in CaBPs7 and 8 were of functional relevance we first generated truncation variants of each protein terminating at the amino acid directly before the beginning of the predicted TMD.
This finding is of special relevance as first-time mothers are increasingly part of the labor force in Lebanon [ 36].
Furthermore, since patients' quality of life is of particular relevance especially for second-line treatment there is a need for a regimen with a favourable toxicity profile.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com