Although clinical and biochemical euthyroidism is readily restored in the majority of patients treated with levothyroxine (L-T4), an important subgroup manifests apparently anomalous TFTs, which can be a source of considerable frustration and confusion both for patient and clinician alike.
Though Yasir Arafat arguably enjoys much more unfettered authority in his camp than Mr. Sharon in his, the Palestinian leader's management style has been a matter of considerable frustration.
"Our performance in Europe this season has been the cause of considerable frustration," said chair Ian Bankier.
The software's speed and inability to seamlessly link with day-to-day software was a source of considerable frustration.
As acknowledged, IBS represents significant demands on the health service and is a source of considerable frustration amongst patients and health care professionals.
That this had not yet occurred was a source of considerable frustration for many in the network groups: "We come up with fantastic guidelines, policies, frameworks, clinical protocols, recommendations.
Theater management is also an area of considerable frustration for many producers and artists, especially those from overseas.
Nineteen of these doctors spontaneously described a "service ethic", relating overall satisfaction with public hospital work and a sense of being needed, in spite of considerable frustrations.
It's not the end of the road for China-North Korea relations just yet, but it's clear there is considerable frustration and indeed disappointment in Beijing over Pyongyang's recent behaviour.
